rorc inhibitor sr2211 Search Results


rorc inhibitor sr2211  (Bio-Techne corporation)
96
Bio-Techne corporation rorc inhibitor sr2211
Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or <t>SR2211</t> (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.
Rorc Inhibitor Sr2211, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rorc inhibitor sr2211/product/Bio-Techne corporation
Average 96 stars, based on 1 article reviews
rorc inhibitor sr2211 - by Bioz Stars, 2026-03
96/100 stars
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sr2211  (Cayman Chemical)
90
Cayman Chemical sr2211
Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or <t>SR2211</t> (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.
Sr2211, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sr2211/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
sr2211 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or SR2211 (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

doi: 10.1038/s41467-022-32089-3

Figure Lengend Snippet: Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or SR2211 (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.

Article Snippet: The specific RORC inhibitor SR2211 was purchased commercially (Tocris/Biotechne) and resuspended in DMSO at a stock of 100 mM.

Techniques: Expressing, Two Tailed Test

Single ILCP from healthy donors ( n = 16) were cultured with either 0.01% DMSO (black circles) or SR2211 (10 μ M) (red). a Frequencies of unipotent (EOMES + ILC1, EOMES-ILC1, ILC2, ILC3, None) and total multipotent clones per individual healthy donor. b Frequencies of types of multipotent clones. c Overall distributions of clones grown in either DMSO alone or SR2211. d Overall frequencies of all clones expressing IFNγ, IL-13, IL-17A and IL-22. e Cloning efficiency of donors grown in either DMSO or SR2211. Comparisons performed using ( a – b , d ) Two-way ANOVA with matching using Šidák’s multiple comparisons tests, (details in Supplementary Table ) ( c ) chi-square test (observed vs expected; details in Supplementary Table ) and e paired t-test (two-tailed) (details in Supplementary Table ). ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data represented as individual donors matched across conditions, compiled from 7 experiments. Source Data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

doi: 10.1038/s41467-022-32089-3

Figure Lengend Snippet: Single ILCP from healthy donors ( n = 16) were cultured with either 0.01% DMSO (black circles) or SR2211 (10 μ M) (red). a Frequencies of unipotent (EOMES + ILC1, EOMES-ILC1, ILC2, ILC3, None) and total multipotent clones per individual healthy donor. b Frequencies of types of multipotent clones. c Overall distributions of clones grown in either DMSO alone or SR2211. d Overall frequencies of all clones expressing IFNγ, IL-13, IL-17A and IL-22. e Cloning efficiency of donors grown in either DMSO or SR2211. Comparisons performed using ( a – b , d ) Two-way ANOVA with matching using Šidák’s multiple comparisons tests, (details in Supplementary Table ) ( c ) chi-square test (observed vs expected; details in Supplementary Table ) and e paired t-test (two-tailed) (details in Supplementary Table ). ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data represented as individual donors matched across conditions, compiled from 7 experiments. Source Data are provided as a Source Data file.

Article Snippet: The specific RORC inhibitor SR2211 was purchased commercially (Tocris/Biotechne) and resuspended in DMSO at a stock of 100 mM.

Techniques: Cell Culture, Clone Assay, Expressing, Two Tailed Test